"The anti-cancer effects of all-trans retinoic acid in breast cancer have been demonstrated in some studies. However, since the precise mechanism of its action remains unclear, a study was conducted to investigate this issue," said Dr. Hamed Manoochehri, an Assistant Professor at the Persian Gulf Marine Biotechnology Research Center of Bushehr University of Medical Sciences.
"The study's findings revealed that all-trans retinoic acid exhibits anti-cancer effects in breast cancer by influencing key genes such as the estrogen receptor (ESR1) and those involved in cell death regulation (MDM2) and cell proliferation (CCND1/CDK4)," added Dr. Manoochehri.
Dr. Manoochehri mentioned: "All-trans retinoic acid directly or indirectly affects these genes, leading to cancer suppression by modulating their expression."
"Based on these findings, each of the genes mentioned above could serve as potential targets for developing new drugs or redesigning existing ones, paving the way for cancer gene therapy, particularly in breast cancer treatment," said Dr. Manoochehri.

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